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Title   대장직장암환자에서 구제요법으로서의 5-Fluorouracil 장기간 지속정주 효과 ( Protracted Venous Infusion of 5-Fluorouracil as a Chemotherapy in Colorectal Cancer )
Publicationinfo   1999 Jan; 031(01): 120-126.
Key_word   5-fluorouracil, Colorectal cancer, Protracted infusion, Salvage chemotherapy
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Abstract   Purpose: The administration of 5-fluorouracil (5-FU) by protracted intravenous infusion is an alternative to the bolus administration of 5-FU in patients with advanced colorectal cancers. This study was performed to evaluate the response rate and toxicities of protracted infusion of 5-FU in patients with advanced or recurrent colorectal cancers who had been treated with 5-FU by bolus or shortterm continuous administration. Materials and Methods: Between March 1995 and June 1997, twenty-eight patients with advanced colorectal cancer previously exposed to 5-FU based chemotherapy were enrolled in this triaL Patients received 5-FU (250 mg/m(2)/day days 1-28) or 5-FU plus leucovorin (5-FU; 200 mg/m/day days 1-28, leucovorin; 20 mg/m IV days 1, 8, 15, 21) by ambulatory infusion pump. Treatment course was repeated every 42 days until disease progression. Result: Twenty-eight patients entered. All 28 patients were assessable for response and toxicity. Five (19%) patients achieved a partial response, with the median response duration of 15 weeks (range; 7-22 weeks), and median survival time of entire patients was 54 weeks (range 7-151+ weeks). Gastrointestinal toxicity, specifically stomatitis was a major toxicity (grade 2, 12%; grade 3, 4%), but hand-foot syndrome was less frequent (5%) compared with other trials with protracted infusion of 5-FU reported in the literature. Hematologic toxicity was generally of low grade. Conclusion: Prolonged intravenous infusion of 5-FU can produce a response rate of 19% with low toxicity among patients refractory to bolus or short-term infusion of S-FU.
저 자   정현식(Hyun Sik Jeong),김원석(Won Seog Kim),정숙인(Sook In Jung),이종태(Jong Tae Lee),김기현(Ki Hyun Kim),윤성수(Sung Soo Yoon),강원기(Won Ki Kang),이홍기(Hong Ghi Lee),박근칠(Ken Chil Park),이풍렬(Poong Lyul Rhee),김재준(Hae Jun Kim),전호경(Ho Kyun Chun),박찬형(Chan Hyung Park)